hrp0082p1-d3-16 | Adrenals & HP Axis (1) | ESPE2014

A Novel Mutation in Exon 5 of TP53 Gene in a Familial Adrenocortical Carcinoma

Simsek Enver , Binay Cigdem , Tokar Baran , Dundar Emine , Demiral Meliha

Background: Adrenocortical carcinoma (ADCC) is a rare cancer in children and differs significantly in epidemiology, clinical characteristics, and biologic features from their counterparts in adults. Germline mutations of the TP53 tumor suppressor gene are associated with cancer predisposition in families with the Li-Fraumeni syndrome.Aim: To report a young girl with family a history of ADCC who presented with severe virilisation secondary to ADC...